Mittelerde Meeting 2025

Programme

Below you find the daily schedule for the conference.
Please note that this timetable is subject to change.

Day 1

10:00

Registration

Session 1 - Math-Graphs

11:00

Welcome

11:05

Talk 1: Sayan Mukherjee (MPI/ University Leipzig)

Scale Reliant Interference

11:25

Talk 2: Wassili Dimitriew (FSU Jena)

Man and Machine (and Fungus): Genome- scale metabolic reconstruction leveraged by large language models

11:45

Talk 3: Varada Khot (FSU Jena)

From Jacks-of-all-trades to masters of some: phylogenomic insights into microbial specialization using gene-tree reconciliation

12:05

Talk 4: Heitor Baldo (University Leipzig)

Algorithms for Approximating the Spectral Density of Multilayer Directed Graphs and Hypergraphs

12:25

Self-organized Lunch

recommendations tba

Session 2 - System Biology

13:40

Talk 5: Adrian Friebel (University Leipzig)

Spatially Resolved Single-Cell Analysis of the Tumor Microenvironment and TGF- Signaling Using Multiplex Imaging and Deep Learning

14:00

Talk 6: Marie Steinacker (University Leipzig)

Predicting chemotherapy-induced thrombotoxicity by NARX neural networks and knowledge-driven transfer learning

14:20

Talk 7: Maximilian Joas (University Leipzig)

Zero-Shot, Big-Shot, Active-Shot - How to estimate cell confluence, lazily

14:40

Talk 8: Carolin Schimmelpfennig (University Halle)

High-throughput characterization of stomatal traits in WM800 MAGIC wheat population

15:00

Coffee Break

Session 3 - DNA

15:30

Talk 9: Pierre Joubert (TU Dresden)

Understanding how genome stability is encoded at the sequence level using the DNA language model GROVER

15:50

Talk 10: Jakub Zastapilo (TU Dresden)

Region-Specific Alterations in 3D Genome Architecture Following X-Ray Irradiation

16:10

Talk 11: Maria Schreiber (FSU Jena)

Sweet Synteny - Unraveling Microsynteny Patterns

16:30

Invited Talk: Michael Hiller (University Frankfurt)

TOGA2 improves speed and accuracy of comparative gene annotation

(further information)

Postersession + Dinner

17:30

Dinner

18:00

Session A

posters tba

19:00

Session B

posters tba

20:00

Open Discussions

End of Day (22:00)

Day 2

Session 4 - Pixels-Graphs-Dots

09:00

Talk 12: Andreas Kröpelin (University Hospital Jena)

Connecting the dots: A probabilistic model for biomolecular latent space trajectories

09:20

Talk 13: Tieu-Long Phan (University Leipzig)

KGG: A Knowledge-Guided Graph Self-Supervised Framework for Advancing Molecular Property Predictions

09:40

Talk 14: Stefan Höhme (University Leipzig)

Machine-learning superpixels for 3D multiscale modelling of liver diseases

10:00

Coffee Break

Session 5 - Structural / Molecules

10:30

Talk 15: Inna Lavrik (OVGU Magdeburg)

Dissecting apoptosis regulation via pharmacological targeting

10:50

Talk 16: Luisa Kärmer (University Vanderbilt/ Leipzig)

AI-Accelerated Quantum Chemistry for Drug Design

11:10

Talk 17: Adnan Jasarevic (TU Dresden)

Modelling strategies to derive physico-chemical properties of the DNA double helix from DNA sequence data

11:30

Talk 18: Marija Sorokina (University Leipzig)

Development of peptide binders with ML- & physics-based methods for GPCRs

11:50

Talk 19: Tushar Patel (FLI Jena)

Gestational Age prediction using CpG clusters in regularized regression

12:10

Self-organized Lunch

recommendations tba

Session 6 - Omics

13:20

Talk 20: Michael Rade (Frauenhofer IZI Leipzig)

Development of a time series single-cell transcriptomic CAR T-cell atlas to explore the dynamics of CAR T-cell therapy

13:40

Talk 21: Dmitrii Severinov (TU Dresden)

From Damage to Healing: Following the Regeneration Process in Zebrafish with Single-Cell Multiomics and Gene Regulatory Networks

14:00

Talk 22: Mark Olenik (FLI Jena)

Tracking Biological Age - A Proteomic Clock with Consistent Longitudinal Performance

Session 7 - Viral

14:20

Invited Talk: Denise Kühnert (RKI)

tba

(further information)

15:00

Coffee Break

15:30

Talk 23: Rainer König (FSU Jena)

Integrative Identification of Host Dependency Factors in Key Viral Pathogens Using Machine Learning

15:50

Talk 24: Tom Eulenfeld (FSU Jena)

AnchoRNA - Guiding the alignment of full viral genomes

16:10

Talk 25: Eva Aßmann (RKI)

A spatiotemporal deep learning appraoch for SARS-CoV-2 wastewater forecasts

Farewell (16:30)

Organizers

Contact

General Information

mittelerde@uni-leipzig.de

Dr. Jan Ewald

jan.ewald@uni-leipzig.de

Prof. Dr. Peter Florian Stadler

stadler@bioinf.uni-leipzig.de

Dr. Stephan Bernhart

bernhart@izbi.uni-leipzig.de

Prof. Dr. Jens Meiler

jens@meilerlab.org

Supported by

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